For most, though, these rare side effects are worth withstanding if CBD can help them with inflammation issues, anxiety, and more. This is one of the reasons why the stuff has grown so popular of late.

I am not a doctor or medical professional so I would not be able to answer your question. I recommend you speak with your prescribing doctor before taking CBD oil. Some good places to research drug interactions with CBD would be this post as well as this post from Project CBD. It was found to increase the bioavailability of Hexobarbital, a barbiturate derivative with sedative and hypnotic effects that’s often sold in both sodium salt and acid forms like Tobinal, Evipan, and Citopan. While cannabis may increase the potency or effectiveness of other drugs, close monitoring by your physician or a medical professional is important.

Further, adverse effects of Epidiolex are reported for the recommended maintenance dose of 10 mg/kg/day as well as the maximum recommended dose of 20 mg/kg/day (Table 4). Prediction of risk-benefit should consider ADEs in light of expected dose variability, user weight, as well as other presented factors. These interactions can potentiate a wide array of ADEs and negative clinical outcomes specific to the substrate and indicated treatment.

Clinical trials suggest that this side effect may also diminish with prolonged therapy so, when needed, a lower starting dose and slower titration may allow for continued CBD use until tolerance is achieved . For recreational consumer use of CBD, such tolerance may never be achieved without sustained use. Considering variation in cumulative ADE risk, consumer use versus medical or complementary health use may vary. Many users may sporadically be exposed to CBD while others may consume it daily or multiple times per day. Many ADEs such as somnolence, insomnia, and sleep disturbances are likely to occur even with sporadic and acute exposure while infections, transaminase elevations, and weight loss will require prolonged exposure.

If you are considering using CBD oil to manage epilepsy symptoms, please speak with your doctor first. While researchers are finding many benefits to CBD oil, from arthritis to stress relief, the field of research is still new. Researchers don’t yet know how CBD might interact with the full universe of medications available today. They have discovered, however, that CBD may affect the liver’s ability to metabolize certain drugs, much like grapefruit. Studies have shown that CBD works differently in the body than other cannabinoids, specifically affecting the liver cytochrome P450 pathway.

I went to my local CBD store to inquire about CBD oil and lotion for my father. The sales person assured me that there would be no drug interactions, but I researched anyway. I plan on printing this out and bringing it to the store to educate them.

For CBD specifically, safety is further assumed given CBD is currently broadly available and lacks the euphoric, psychoactive properties of tetrahydrocannabinol (THC). However, recognition that this general benignancy of CBD is perhaps only applicable to younger, healthier individuals using cannabis recreationally creates a tremendous patient safety concern in this new era. Particularly given the potential for other adverse drug events (ADEs) and drug–drug interactions (DDIs) with CBD. At the same time, it’s important to be aware that CBD can interact with some medications. Taking it at the same time as other drugs can affect CBD’s dosage and effects, and can even change how your body breaks it down.

Thus, caution should be taken with any concomitant use between CBD and many common medications used by otherwise healthy persons. Lastly, it should always be considered that CBD users might be exposed to one or more interacting drug, which can potentiate ADE/DDIs when multiple drugs overlap pharmacokinetically and/or pharmacodynamically. Both user populations, as well as much of the healthcare community, seemingly extrapolate the safety of cannabis and cannabis-derived substances like CBD from its long history of recreational use.

On its own—at least in the short-to-medium term—cannabidiol (CBD) is thought to be largely safe. Sure, a few people who use this non-inebriating weed compound for recreation or for its potential medical benefits may experience mild tiredness, appetite changes, or an occasional case of diarrhea.